Missing Molecule Prevents Puberty and Ability to Smell

Missing Molecule Prevents Puberty and Ability to Smell.jpg

A molecule important in blood vessel formation and brain wiring is also essential for the onset of puberty, finds new research led by UCL and the University of Milan. The researchers found a genetic fault that prevented this molecule, called SEMA3E, from being working correctly in two brothers with Kallman Syndrome, an inherited condition that prevents people from undergoing puberty or being able to smell. They then studied mice without SEMA3E to see how its loss affected their development.

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